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KMID : 1059520210650050320
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Journal of the Korean Chemical Society
2021 Volume.65 No. 5 p.320 ~ p.326
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Effect of Crosslinking Agent Structure on Drug Release and Antibacterial Effect of Contact Lenses
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Lee Pil-Heon
Lee Hyun-Mee
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Abstract
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This study investigated the effect of the structure of the crosslinking agent used in contact lens polymerization on the physical properties and drug dissolution of contact lenses.es Contact lenses were manufactured using 0.3% and 3% of 4 types of crosslinking agents, respectively, and ofloxacin was used as the drug. Contact lenses using hydrophilic crosslinking agents improved water contents and wettability, and the more hydrophilic functional groups, the greater the effect. Contact lenses with a high concentration of crosslinking agent had a low concentration of eluted drug and a longer release time. The cross-linking agent structure of contact lenses had an effect on improving the performance of contact lenses and controlling drug release.
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KEYWORD
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Contact lens, Crosslinking agent, Drug release, Antibacterial effect, Wettability
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